Narcolepsy: Biogenic amine deficits in an animal model Academic Article Article uri icon


MeSH Major

  • Exons
  • Forms and Records Control
  • Mental Disorders
  • Polymorphism, Single Nucleotide


  • Concentrations of biogenic amine metabolites in discrete brain areas differed significantly between dogs with genetically transmitted narcolepsy and age- and breed-matched controls. Dopamine and 3,4-dihydroxyphenylacetic acid were consistently elevated in the brains of narcoleptic animals, while homovanillic acid was not. Narcoleptic animals consistently exhibited lower utilization of dopamine and higher intraneuronal degradation of dopamine but no uniform decrease in serotonin utilization. Hence neuropathology appears to be associated with genetically transmitted canine narcolepsy. The data indicate a nonglobal depression of dopamine utilization or turnover or both.

publication date

  • June 16, 1983



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1126/science.6188216

PubMed ID

  • 6188216

Additional Document Info

start page

  • 629

end page

  • 32


  • 220


  • 4597