Phenomenon of formation of giant fat-containing cells in human bone marrow cultures induced by human serum factor: Normal and leukemic patterns Academic Article uri icon


MeSH Major

  • Bone Marrow Cells
  • Leukemia


  • Normal human sera induce the formation of fat-containing cells (FCC) in human bone marrow cultures. A nearly complete monolayer of FCC is formed after 7-14 days of cultivation with 20% human sera in the medium. FCC-inducing activity (FCCIA) is nondialyzable through 14,900-dalton cutoff membrane and is stable at 56 degrees C for 30 min. Abundant FCCIA was found in 83% of normal human sera but in only 20% of sera from untreated patients with different hemopoietic disorders and in 32% of treated leukemic patients. It is suggested that FCCIA may be involved in regulation of the bone marrow microenvironment an that it varies in normal individuals and in patients with different diseases.

publication date

  • September 29, 1983



  • Academic Article



  • eng

PubMed Central ID

  • PMC384142

PubMed ID

  • 6192444

Additional Document Info

start page

  • 4847

end page

  • 50


  • 80


  • 15 I