Variants of alpha-melanocyte stimulating hormone in rat brain and pituitary: Evidence that acetylated α-MSH exists only in the intermediate lobe of pituitary Academic Article Article uri icon


MeSH Major

  • Graft Rejection
  • Kidney Transplantation
  • Primary Graft Dysfunction
  • RNA, Messenger


  • The alpha-melanocyte stimulating hormone (α-MSH) variants from rat and human pituitary and rat brain have been analyzed in detail by radioimmunoassay (RIA) interfacing with various chromatography systems. No authentic α-MSH was detected in extracts of rat brain regions or human pituitary. In these tissues the only α-MSH variant detected was characterized as des-acetyl α-MSH. Conversely, acetylated α-MSH was found to be the predominant form in rat pituitary. In addition to α-MSH, extracts from both rat and cow pituitary were found to contain an α-MSH variant with the characteristics of an O-N-diacetyl derivative. © 1982.

publication date

  • June 15, 1982



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0006-291X(82)91797-1

PubMed ID

  • 7115386

Additional Document Info

start page

  • 910

end page

  • 9


  • 106


  • 3