Brain distributions of α-neo-endorphin and β-neo-endorphin: Evidence for regional processing differences Academic Article Article uri icon


MeSH Major

  • Graft Rejection
  • Kidney Transplantation
  • Primary Graft Dysfunction
  • RNA, Messenger


  • The leu-enkephalin containing opioid peptides α-neo-endorphin and β-neo-endorphin [i.e., α-neo-endorphin(1-9)] were measured in rat brain region extracts with two highly specific radioimmunoassays. The molar ratio of α-neo-endorphin to β-neo-endorphin was extremely variable among brain regions. In hypothalamus and posterior pituitary β-neo-endorphin levels were almost as high as α-neo-endorphin levels. In contrast, in the striatum α-neo-endorphin was 30-fold more concentrated than β-neo-endorphin. In all other brain regions α-neo-endorphin was present in 3 to 20-fold higher concentrations than β-neo-endorphin. The β-neo-endorphin immunoreactive material was found to comigrate with authentic β-neo-endorphin on reverse phase HPLC. These findings suggest that in certain brain regions but not in others processing mechanisms exist which can generate β-neo-endorphin through processing of α-neo-endorphin or its precursors. © 1982.

publication date

  • September 16, 1982



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0006-291X(82)91834-4

PubMed ID

  • 7150301

Additional Document Info

start page

  • 81

end page

  • 8


  • 108


  • 1