INCIDENCE OF SECOND MALIGNANT NEOPLASMS IN CHILDREN: RESULTS OF AN INTERNATIONAL STUDY Academic Article Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Leukemia, Lymphoid
  • Methotrexate

abstract

  • The incidence of second malignant neoplasms (SMNs) in children was estimated from data provided by ten paediatric oncology centres. During 1950-70 nearly 15 000 new patients were seen at these institutions. With follow-up through 1979, 113 eligible cases of SMN were reported. To estimate the number of person-years at risk, a common set of survival distributions, specific for tumour type and calendar period, was applied to the patient entry data at each institution. The annual incidence of SMNs 5-15 years after diagnosis of first tumour was found to be 188/100 000; this represents an approximate ten-fold increase over the age-adjusted expected rate of cancer in the general population. The corresponding incidence during the first 5 years was 85/100 000/year, a seven-fold increase in risk. The estimated cumulative probability of SMN reached 3.3% at 20 years.

publication date

  • December 11, 1982

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(82)91524-0

PubMed ID

  • 6128611

Additional Document Info

start page

  • 1326

end page

  • 31

volume

  • 320

number

  • 8311