Identification by HLA typing of intrauterine-derived maternal T cells in four patients with severe combined immunodeficiency Academic Article uri icon

Overview

MeSH Major

  • HLA Antigens
  • Histocompatibility Antigens Class II
  • Immunologic Deficiency Syndromes
  • T-Lymphocytes

abstract

  • After the initial observation of engraftment of nonfunctional intrauterine-derived maternal T cells in a patient with severe combined immunodeficiency without graft-versus-host disease, we prospectively examined all new patients with severe combined immunodeficiency for the presence of such engrafted cells in order to determine the incidence of this phenomenon. Peripheral lymphocytes were separated into E-rosette-positive and E-rosette-negative populations and then typed separately for HLA, HLA-DR antigens and other lymphocyte markers on both the E-rosette-positive and negative cells were also determined. Of 16 patients examined, four were determined to have E-rosette-positive maternal lymphocytes. The engrafted cells were functionally inactive during in vitro tests of cell-mediated immune function. In repeated examinations performed when the four patients were between the ages of six and 15 months, three of the four had neither clinical nor histologic evidence of classic graft-versus-host disease. Our studies indicate that engraftment of maternal T lymphocytes occurs with considerable frequency, but that this engraftment may not lead to overt clinical graft-versus-host disease. The characteristics of these four patients are described in this report.

publication date

  • December 1982

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7050708

Additional Document Info

start page

  • 662

end page

  • 6

volume

  • 307

number

  • 11