Form and function of retroviral proviruses Review uri icon

Overview

MeSH Major

  • Retroviridae

abstract

  • Retroviruses have proved to be useful reagents for studying genetic and epigenetic (such as regulatory) changes in eukaryotic cells, for assessing functional and structural relationships between transposable genetic elements, for inducing insertional mutations, including some important in oncogenesis, and for transporting genes into eukaryotic cells, either after natural transduction of putative cellular oncogenes or after experimental construction of recombinant viruses. Many of these properties of retroviruses depend on their capacity to establish a DNA (proviral) form of their RNA genomes as a stable component of host chromosomes, in either somatic or germinal cells.

publication date

  • December 1982

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 6177038

Additional Document Info

start page

  • 812

end page

  • 20

volume

  • 216

number

  • 4548