Physiological influences on perfusion imaging in transient myocardial ischaemia: Importance of early distribution of thallium-201 Academic Article uri icon

Overview

MeSH Major

  • Coronary Disease
  • Heart
  • Radioisotopes
  • Thallium

abstract

  • We tested the hypothesis that visualisation of defects on thallium-201 (201Tl) myocardial perfusion images (MPI) depends on the duration of the ischaemic state between 201Tl injection and the time of reperfusion of an occluded coronary artery. Praecordial imaging with a gamma camera was performed in 24 anaesthetised, open-chest dogs with transient coronary occlusion. Results indicated that if the duration of the ischaemic state after 201Tl injection was less than 3 min before reperfusion, then the MPI 5 to 15 min after 201Tl injection was falsely negative (201Tl activity in zone (IZ)/normal zone (NZ)greater than 0.85). Dogs which were ischaemic more than 5 min always had MPI defects 5 to 15 min after 201Tl injection (IZ/NZ201Tl ratio less than 0.85). MPI results (201Tl IZ/NZ) 15 min after 201Tl injection were determined by the duration of the ischaemic state after 201Tl injection (r = -0.86) because prolonged ischaemia allowed 201Tl to distribute from blood to myocardium before reperfusion: 201Tl (IZ/NZ( = 0.356 +/- 1.00 (fraction of total 201Tl remaining in blood at the end of the ischaemic state), r = 0.94.

publication date

  • April 16, 1982

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7060060

Additional Document Info

start page

  • 47

end page

  • 54

volume

  • 16

number

  • 1