The Effect of Repeated Hemoperfusion Over Charcoal in the Conscious Rat on Liver Pathophysiology Academic Article Article uri icon


MeSH Major

  • Echocardiography
  • Mitral Valve Insufficiency
  • Ultrasonography, Doppler


  • An investigation has been made into the effects of repeated charcoal hemoperfusion in the rat on liver pathophysiology. Animals underwent hemoperfusion over Norit RBX1 charcoal using a technique which allowed perfusion in the unrestrained and conscious state, thus minimizing any possible effects from stress and eliminating the necessity of repeated anesthesia. Controls consisted of animals subjected to perfusion through empty columns and animals cannulated only. Liver weight, function, and histology were recorded at various times following hemoperfusion and control procedures. The results show that repeated charcoal hemoperfusion is well tolerated in the rat and can be performed safely with no deleterious effects on liver tissue.

publication date

  • January 1982



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1111/j.1525-1594.1982.tb04079.x

PubMed ID

  • 7125959

Additional Document Info

start page

  • 169

end page

  • 74


  • 6


  • 2