Corticosterone: A critical factor in an opioid form of stress-induced analgesia Academic Article Article uri icon

Overview

MeSH Major

  • Exons
  • Forms and Records Control
  • Mental Disorders
  • Polymorphism, Single Nucleotide

abstract

  • The finding that some opioid-mediated forms of stress-induced analgesia are antagonized by hypophysectomy and dexamethasone has led to the suggestion that beta-endorphin, released from the pituitary, may mediate these analgesic reactions. "Long-term analgesia" (an opioid-mediated form of stress-induced analgesia), which is blocked by dexamethasone and hypophysectomy, was also blocked by adrenalectomy and reinstated with corticosterone therapy. Corticosterone is proposed to play a permissive role in long-term analgesia and to be a critical hormone mediating this phenomenon.

publication date

  • November 15, 1982

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1126/science.7063862

PubMed ID

  • 7063862

Additional Document Info

start page

  • 1530

end page

  • 2

volume

  • 215

number

  • 4539