Combination chemotherapy of esophageal carcinoma using cisplatin, vindesine, and bleomycin Academic Article Article uri icon


MeSH Major

  • Mycosis Fungoides
  • Sezary Syndrome


  • Sixty-one patients with epidermoid carcinoma of the esophagus have been treated with a three drug combination of cisplatin, vindesine, and bleomycin. Of 53 patients currently evaluable for response, 29 (55%) have had partial remissions: 7/16 with metastatic, and 22/37 with local-regional disease. The median duration of response in metastatic patients is eight months. Of 28 patients treated preoperatively, 23 (82%) had resectable disease. The major toxicities seen were nephrotoxicity and myelosuppression. Cisplatin, vindesine and bleomycin is an effective combination in the treatment of esophageal carcinoma. Effects on long-term survival cannot yet be evaluated.

publication date

  • January 1982



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19820315)49:6<1174::AID-CNCR2820490618>3.0.CO;2-W

PubMed ID

  • 6174199

Additional Document Info

start page

  • 1174

end page

  • 7


  • 49


  • 6