Effect of nerve growth factor on regeneration of goldfish optic axons Academic Article Article uri icon


MeSH Major

  • Nerve Regeneration
  • Optic Nerve
  • Proteins


  • Axonal outgrowth following a crush of the goldfish optic nerve was enhanced if nerve growth factor (NGF) was administered by intraocular injection or by local application to the lesion site. Various forms of NGF (beta, 2.5S and 7S) were effective, producing a 20-40% decrease in the time required for recovery of the startle reaction to a bright light. A corresponding increase in axonal outgrowth was revealed by histological examination of the optic nerves. The effect produced by a single intraocular injection given at the time of the lesion was not further increased by subsequent injections. Up to 14 days after the lesion, the size of the retinal ganglion cell bodies and the incidence of nucleoli detectable by light microscopy were not affected by the NGF treatment.

publication date

  • April 29, 1982



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0006-8993(82)90108-1

PubMed ID

  • 7093657

Additional Document Info

start page

  • 329

end page

  • 39


  • 238


  • 2