Leukotriene D4: A potent coronary artery vasoconstrictor associated with impaired ventricular contraction Academic Article Article uri icon

Overview

MeSH Major

  • General Surgery

abstract

  • Leukotriene D4 (2 c 10(-9) mole), injected into the left circumflex coronary artery of anesthetized sheep, produced profound coronary vasoconstriction and impaired regional ventricular wall motion. This cardiac effect was neither inhibited by prior treatment of the sheep with a cyclooxygenase inhibitor nor associated with thromboxane B2 release into the coronary sinus. Intravenous FPL 55712 completely abolished the coronary vasoconstriction of leukotriene D4, but a significant reduction of regional wall shortening persisted.

publication date

  • October 11, 1982

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1126/science.6808665

PubMed ID

  • 6808665

Additional Document Info

start page

  • 841

end page

  • 3

volume

  • 217

number

  • 4562