Inhibition of Con A mitogenesis by serum from procainamide-treated patients and patients with systemic lupus erythematosus Academic Article uri icon

Overview

MeSH Major

  • Concanavalin A
  • Lupus Erythematosus, Systemic
  • Lymphocyte Activation
  • Procainamide

abstract

  • Serum obtained from patients with spontaneous systemic lupus erythematosus or from patients treated at least 3 months with procainamide could specifically inhibit Con A mitogenesis of cultured peripheral blood mononuclear cells obtained from procainamide-treated patients or from normal donors. Transfer of procainamide treated patients to N-acetylprocainamide eliminated the blocking factor from their serum. The blocking factor is not procainamide itself since adding the drug to normal serum and only slight effects on mitogenesis of normal peripheral blood mononuclear cells. These data suggest that systemic lupus erythematosus and procainamide-induced lupus may differ in the relative reversibility of a regulatory defect associated with a Con A responsive population of peripheral blood mononuclear (PBM) cells.

publication date

  • January 1982

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6178682

Additional Document Info

start page

  • 33

end page

  • 45

volume

  • 11

number

  • 1