Intracellular degradation of newly synthesized collagen. Review uri icon

Overview

MeSH

  • Animals
  • Cells, Cultured
  • Chickens
  • Cricetinae
  • Guinea Pigs
  • Haplorhini
  • Humans
  • Hydroxyproline
  • Mice
  • Proline
  • Rabbits
  • Rats

MeSH Major

  • Collagen

abstract

  • The intracellular degradation of newly synthesized collagen is a cellular pathway that accounts for the destruction of 10-60% of collagen synthesized by a variety of cell types prior to secretion. This pathway can serve in a regulatory role to limit the secretion of defective molecules, and, in response to some extracellular mediators, regulates the amount and type of collagens secreted. In addition, this pathway may contribute to the pathogenesis of a variety of conditions affecting the extracellular matrix including fibrosis, diabetes mellitus, and scurvy.

publication date

  • July 1982

has subject area

  • Animals
  • Cells, Cultured
  • Chickens
  • Collagen
  • Cricetinae
  • Guinea Pigs
  • Haplorhini
  • Humans
  • Hydroxyproline
  • Mice
  • Proline
  • Rabbits
  • Rats

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed ID

  • 6806401

Additional Document Info

start page

  • 77s

end page

  • 82s

volume

  • 79 Suppl 1