Angioimmunoblastic lymphadenopathy with hypogammaglobulinemia. Possible role of monocyte suppression Academic Article Article uri icon

Overview

MeSH Major

  • Interferon-beta
  • Janus Kinase 2
  • Point Mutation
  • Polycythemia Vera
  • Polyethylene Glycols

abstract

  • A patient wit angioimmunoblastic lymphadenopathy had low serum immunoglobulin values and no antibodies to injected immunogens. This occurred despite the proliferation of polyclonal B cells. T cells were deficient in number and in lymphoproliferative responses, but their helper and suppressor functions were maintained. Ia-antigen bearing leukocytes from the patient stimulated poorly in mixed leukocyte culture. In vitro immunoglobulin synthesis by mononuclear leukocytes form the patient was severely impaired. These leukocytes actively suppressed immunoglobulin synthesis by normal cells from healthy subjects in co-culture. The responsible cell had characteristics of a monocyte. The suppression was selective for humoral immunity and was manifest despite normal numbers of monocytes. It appears that heterogeneous immunoregulatory abnormalities can underlie the syndrome of angioimmunoblastic lymphadenopathy. Furthermore, monocyte suppressor abnormalities may be implicated in clinical disease phenomena.

publication date

  • January 1982

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0002-9343(82)90862-2

PubMed ID

  • 6211980

Additional Document Info

start page

  • 998

end page

  • 1004

volume

  • 72

number

  • 6