125I interstitial implants in the RIF-1 murine flank tumor: An animal model for brachytherapy Academic Article uri icon


MeSH Major

  • Brachytherapy
  • Iodine Radioisotopes
  • Neoplasms, Experimental


  • The development of a model for interstitial brachytherapy that uses high-activity, removable 125I sources in the RIF-1 murine flank tumor is reported. Experimental end points are clonogenic cell and tumor regrowth delay assays. For the clonogenic cell assay, interstitial radiation is delivered at total doses of 500-10,000 rad at dose rates of 0.9-2.7 rad/min to cells in annuli of tissue in the tumor. Dose-survival curves are characterized by an initial shoulder followed by a straight (exponential) portion, with D0 similar to that of the curve obtained by external irradiation of the RIF-1 tumor in a self-contained cesium irradiator at similar dose rates. Tumor regrowth curves have been obtained for minimum tumor doses of 500-5000 rad; marked tumor regression has been observed with minimum tumor doses as low as 2000 rad, but results are not as reproducible as the results obtained with the clonogenic cell assay.

publication date

  • January 1982



  • Academic Article



  • eng

PubMed ID

  • 6750681

Additional Document Info

start page

  • 624

end page

  • 37


  • 91


  • 3