Special characteristics of cellular immune function in normal individuals of the HLA-DR3 type
Studies with a number of tests of in vitro cellular immune function have shown differences between DR3-positive normal individuals and those of other DR types. Increased Ig synthesis and decreased Con A-induced suppression were the most striking changes observed in this preliminary investigation. Further studies especially with additional suppressor cell assays appear waranted. The possibilities that such changes play a significant role in the development of diseases associated with the DR3 phenotype is discussed. © 1982.
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