Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance Academic Article uri icon

Overview

MeSH Major

  • Anti-Bacterial Agents
  • Ion Channels
  • Macrolides

abstract

  • The voltage dependence of the conductance induced induced in thin lipid membranes by monazomycin is shown here to be caused by voltage-dependent variations in the frequency of channel openings. We also experimentally demonstrate certain interesting properties of the channel activity that are predicted by a chemical kinetic model (Muller and Peskin, 1981), which successfully describes the macroscopic conductance. We conclude that two parallel mechanisms--one autocatalytic, the other simple mass action--exist that allow monazomycin to enter (or leave) the membrane so that the monazomycin molecules can be in a position to form channels.

publication date

  • January 1982

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2228681

PubMed ID

  • 6292331

Additional Document Info

start page

  • 427

end page

  • 49

volume

  • 80

number

  • 3