Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster Academic Article Article uri icon

Overview

MeSH Major

  • Anxiety
  • Depression
  • Thalassemia

abstract

  • Combined analysis of DNA polymorphisms in the human β-globin gene cluster and in cloned β-genes has revealed the association of specific β-thalassaemia mutations and β-gene polymorphisms with particular flanking polymorphisms. A systematic study of cloned genes identified several new mutations, one of which possibly affects transcription. The strategy used may be applicable to other diseases of single-copy genes. © 1982 Nature Publishing Group.

publication date

  • December 1982

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1038/296627a0

PubMed ID

  • 6280057

Additional Document Info

start page

  • 627

end page

  • 31

volume

  • 296

number

  • 5858