Neuroendocrine and neurochemical measurements in depression Academic Article uri icon

Overview

MeSH Major

  • Depressive Disorder
  • Glycols
  • Homovanillic Acid
  • Hydrocortisone
  • Hydroxyindoleacetic Acid
  • Methoxyhydroxyphenylglycol
  • Phenylacetates
  • Thyrotropin

abstract

  • The authors performed dexamethasone suppression tests (DST), TRH infusions, 72-hour urine collections, and lumbar punctures on a group of male depressed patients. Approximately 60% of the patients were DST positive and 33% had a blunted TSH response. Two biologic variables, the 8 a.m. postdexamethasone cortisol and the postprobenecid CSF 5-hydroxyindoleacetic acid (5-HIAA), accounted for over half of the variance in the behavioral measure, the Hamilton score. Plasma cortisol elevation was associated with high 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion; TSH blunting was associated with low urinary MHPG excretion. Comprehensive biologic measures showed certain significant interrelationships and correlations with the severity of depression.

publication date

  • December 1981

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6171169

Additional Document Info

start page

  • 1555

end page

  • 62

volume

  • 138

number

  • 12