Long-term stress-induced analgesia and activation of the opiate system Academic Article uri icon

Overview

MeSH Major

  • Endorphins
  • Pain
  • Stress, Physiological

abstract

  • Exposure of rats to a series of inescapable shocks produced in sequence both an early naltrexone-insensitive and a late naltrexone-reversible analgesic reaction. Activation of the opiate system was necessary and sufficient to produce an analgesic reaction 24 hours later on exposure to a small amount of shock. The amount of inescapable shock which induced naltrexone-reversible analgesia also produced hyperreactivity to morphine 24 hours later.

publication date

  • December 1981

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7268445

Additional Document Info

start page

  • 1409

end page

  • 11

volume

  • 213

number

  • 4514