Dural sinus thrombosis in children with acute lymphoblastic leukemia Academic Article Article uri icon

Overview

MeSH Major

  • Kidney Neoplasms
  • Wilms Tumor

abstract

  • Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase. Headache, nausea, emesis, and lethargy were the presenting signs. The diagnosis was confirmed by arteriography. The cause is presumed to be secondary to hypercoagulability due to asparaginase-induced antithrombin III deficiency. The patients received anticoagulation therapy and recovered completely. Only two of the six reported patients without heparinization survived.

publication date

  • December 1981

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1001/jama.246.24.2837

PubMed ID

  • 6947095

Additional Document Info

start page

  • 2837

end page

  • 9

volume

  • 246

number

  • 24