Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. Academic Article uri icon

Overview

MeSH

  • Adult
  • B-Lymphocytes
  • Chemotactic Factors
  • Female
  • Humans
  • Leukocyte Count
  • Male
  • Middle Aged
  • Pulmonary Fibrosis
  • T-Lymphocytes, Regulatory

MeSH Major

  • Lung
  • Lung Diseases
  • Sarcoidosis
  • T-Lymphocytes

abstract

  • Using the monoclonal antibodies OKT4 and OKT8, we determined the proportions of helper and suppressor T cells in patients with sarcoidosis and high-intensity alveolitis, patients with sarcoidosis and low-intensity alveolitis, patients with idiopathic pulmonary fibrosis (IPF), and normal controls. In controls and patients with IPF, the ratio of helper to suppressor T cells was 1.8:1 in lungs and blood. In contrast, this ratio was 10.5:1 in lungs (P less than 0.001) and 0.8:1 in blood (P less than 0.05) in patients with sarcoidosis and high-intensity alveolitis. The ratio of helper to suppressor T cells was not higher in the lungs or blood of patients with sarcoidosis and low-intensity alveolitis; on the contrary, because of the higher proportions of suppressor cells, the ratio of helper to suppressor cells was lower in both lungs and blood. In studies of function, lung T cells from patients with sarcoidosis and high-intensity alveolitis released monocyte chemotactic factor (a lymphokine critical to granuloma formation) and polyclonally activated B cells to produce immunoglobulins. We conclude that one determinant of lung injury in sarcoidosis in the presence of large numbers of lung helper T cells, which are important in granuloma formation.

publication date

  • August 20, 1981

has subject area

  • Adult
  • B-Lymphocytes
  • Chemotactic Factors
  • Female
  • Humans
  • Leukocyte Count
  • Lung
  • Lung Diseases
  • Male
  • Middle Aged
  • Pulmonary Fibrosis
  • Sarcoidosis
  • T-Lymphocytes
  • T-Lymphocytes, Regulatory

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM198108203050804

PubMed ID

  • 6454846

Additional Document Info

start page

  • 429

end page

  • 434

volume

  • 305

number

  • 8