Danazol, a new steroidal inducer of δ-aminolevulinic acid synthetase Academic Article uri icon

Overview

MeSH Major

  • 5-Aminolevulinate Synthetase
  • Danazol
  • Pregnadienes

abstract

  • Danazol (a derivative of 17 alpha-ethinyl testosterone) has recently been reported to cause clinical exacerbations of acute intermittent porphyria. In the present study, we demonstrate that danazol is an inducer of hepatic delta-aminolevulinic acid synthetase and that it increases hepatocyte porphyrin production using a chick embryo model. The findings provide an explanation for the clinical observations. Although danazol is a porphyrinogenic agent in the chick embryo and humans it has been reported to be ineffective as a porphyrinogen in rats. The present findings, therefore, also confirm the superiority of the chick embryo as a model system for the screening of drugs and chemicals which may have the potential to cause clinical exacerbations of porphyria.

publication date

  • January 1981

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7462405

Additional Document Info

start page

  • 549

end page

  • 52

volume

  • 52

number

  • 3