NALOXONE REVERSAL OF ISCHAEMIC NEUROLOGICAL DEFICITS IN MAN Academic Article Article uri icon

Overview

MeSH Major

  • Cervical Vertebrae
  • Intervertebral Disc Degeneration
  • Intervertebral Disc Displacement
  • Spinal Fusion
  • Tantalum

abstract

  • Two patients with cerebral ischaemia and one patient with cerebral infarction received intravenous infusions of the opiate antagonist naloxone or saline in double-blind manner. Naloxone completely reversed neurological deficits in both patients with cerebral ischaemia, but did not in the patient with cerebral infarction. Naloxone administration produced no changes in blood pressure, pulse rate, respiratory rate, temperature, or arterial blood gases. Intravenous administration of morphine sulphate profoundly exacerbated hemiparesis in one patient without alteration of vital signs; hemiparesis was completely reversed by naloxone. © 1981.

publication date

  • August 8, 1981

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(81)90524-9

PubMed ID

  • 6114322

Additional Document Info

start page

  • 272

end page

  • 5

volume

  • 318

number

  • 8241