Phase i and pharmacological studies of pentamethylmelamine administered by 24-hour intravenous infusion Academic Article uri icon

Overview

MeSH Major

  • Altretamine
  • Antineoplastic Agents
  • Kidney Neoplasms
  • Lung Neoplasms
  • Triazines

abstract

  • A Phase I study of pentamethylmelamine (PMM) was conducted, administering the drug as a 24-hr i.v. infusion once weekly for 3 weeks. Doses ranged from 80 to 3000 mg/sq m/week. Twenty-six evaluable patients received a total of 30 courses of PMM. The median performance status of the patients was 60% (range, 40 to 90%), and the median age was 58 years (range, 43 to 72 years). The highest tolerated dose was 2000 mb/sq m/week. Nausea and vomiting were the dose-limiting toxicities; myelosuppression was neither consistent nor severe. One objective response lasting 10 months was noted in a patient with renal cancer. Pharmacokinetic studies using [ring-14C]PMM demonstrated a postinfusion half-life of 14C of approximately 12 hr, with the majority of the radiolabel excreted in the urine. PMM was introduced as a parenteral form of hexamethylmelamine. The present schedule does not permit administration of PMM in a dose greater than the tolerated dose of hexamethylmelamine and does not appear to offer an advantage over the p.o. use of the parent compound.

publication date

  • April 1981

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6783296

Additional Document Info

start page

  • 1402

end page

  • 6

volume

  • 41

number

  • 4