Postnatal ontogeny of cholecystokinin receptors in rat brain Academic Article uri icon

Overview

MeSH Major

  • Lymph Node Excision
  • Prostate
  • Prostatectomy
  • Prostatic Neoplasms

abstract

  • The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.

publication date

  • May 25, 1981

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(81)91269-5

Additional Document Info

start page

  • 237

end page

  • 41

volume

  • 213

number

  • 1