Developmental regulation of elastin synthesis Academic Article uri icon


MeSH Major

  • Braces
  • Exercise Therapy
  • Intervertebral Disc
  • Low Back Pain
  • Spinal Diseases


  • The regulation of elastin production has been evaluated and compared in two systems in the developing sheep: nuchal ligament and lung. Absolute rates of production in explant culture were estimated by immunoprecipitation of newly synthesized elastin and determination of precursor pool specific activities. Lung elastin production increased about 2.5-fold while nuchal ligament production increased about 9-fold during the latter half of gestation. In comparison, the activities of elastin messenger RNA(mRNAE) of these tissues were determined in a cell-free system by immunoprecipitation. The increases in mRNAE activity largely paralleled the rises in elastin production, suggesting that elastin synthesis in these tissues is regulated, at least in part, by the availability of translationally active mRNAE.

publication date

  • January 1981



  • Academic Article


Digital Object Identifier (DOI)

  • 10.3109/03008208109152377

Additional Document Info

start page

  • 209

end page

  • 12


  • 8


  • 3-4