Prostacyclin and prostaglandin E1 for severe idiopathic pulmonary artery hypertension Academic Article Article uri icon

Overview

MeSH Major

  • Euthanasia
  • Euthanasia, Passive
  • Jurisprudence

abstract

  • Prostacyclin seems to offer advantages in the treatment of idiopathic pulmonary hypertension not found with other drugs. It is a normal product of vascular endothelium. Infusion of PGI 2 might be expected to offer at least two days of relieving increased pulmonary artery pressure and vascular resistance-by dilating pulmonary vascular smooth muscle and by disaggregation of pulmonary microthromboemboli. Brief periods of PGI 2 infusion in patients with idiopathic pulmonary hypertension may produce prolonged reversal of pulmonary vascular lesions analogous to the success with short-term PGI 2 in peripheral vascular disease.

publication date

  • December 1980

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(80)91522-6

PubMed ID

  • 6103414

Additional Document Info

start page

  • 1083

volume

  • 1

number

  • 8177