Human neutrophil elastase functions as a type III collagen 'collagenase' Academic Article uri icon

Overview

MeSH Major

  • Microbial Collagenase
  • Neutrophils
  • Pancreatic Elastase

abstract

  • Under physiologic conditions, human neutrophil elastase cleaves triple helical human type III collagen into specific fragments in a fashion similar to that of a typical 'collagenase'. In contrast, elastase does not attack the triple helical portion of type I collagen. However, unlike a classic collagenase, which is a metalloenzyme, the action of elastase on type III collagen is prevented by serine protease inhibitors. These findings suggest that the concepts of 'collagenases' and 'elastases' must be broadened and that human neutrophil elastase is capable of mediating a broad range of connective tissue destruction.

publication date

  • December 1980

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6251855

Additional Document Info

start page

  • 1815

end page

  • 22

volume

  • 95

number

  • 4