The role of radionuclide imaging in metastatic disease: The Mount Sinai experience
All patients referred for bone scanning during a three-month period were included in this study. The referral indications, clinical information, and bone scans were reviewed. Of the 463 patients, 387 (83%) were referred for possible neoplasms, and the results of bone, liver, brain, and gallium scanning were compared. The data suggested several general strategies currently employed in working-up patients suspected of malignant disease. The utility of routine liver scans was established, while brain scanning was found not to be helpful in the absence of neurologic signs. While bone pain was found significantly more often in patients with metastases, it was only present in 6% of such lesions. The serum alkaline phosphatase was not a sensitive or specific indicator of bone or liver metastases.