Receptor-mediated endocytosis of alpha2-macroglobulin in cultured fibroblasts Academic Article uri icon

Overview

MeSH Major

  • Cell Membrane
  • Endocytosis
  • alpha-Macroglobulins

abstract

  • Alpha 2-macroglobulin is internalized into cultured fibroblasts by receptor-mediated endocytosis. This ligand binds initially to diffusely distributed receptors on the cell surface which cluster rapidly into bristle-coated pits. Within a few minutes at 37 degrees C, these complexes are internalized into uncoated cytoplasmic vesicles, called receptosomes, which move about in the cell by saltatory motion. These vesicles interact with the Golgi-endoplasmic reticulum-lysosome system in the cell to deliver the ligand to newly formed lysosomes within 30--60 min.

publication date

  • December 1980

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 6160180

Additional Document Info

start page

  • 818

end page

  • 23

volume

  • 28

number

  • 8