Study of the state of ionization of [Leu 5]-enkephalin in the crystal and in solution Academic Article uri icon

Overview

MeSH Major

  • Endorphins
  • Enkephalins

abstract

  • The state of ionization of [Leu5]-enkephalin in the crystal and in solution was studied with the aid of Raman, i.r., and n.m.r. techniques. The results indicate that, in the crystal, enkephalin adopts the dipolar ion form. In water near neutral pH, enkephalin also exists in the dipolar ion form whereas in DMSO-d6 it is a mixture of the dipolar ion and uncharged species. The pK's of alpha-amino and alpha-carboxyl groups are probably closer to each other in DMSO than in H2O.

publication date

  • December 1980

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7461900

Additional Document Info

start page

  • 183

end page

  • 90

volume

  • 16

number

  • 3