β-Endorphin and schizophrenia Academic Article uri icon

Overview

MeSH Major

  • Endorphins
  • Schizophrenia

abstract

  • To study the effects of beta-endorphin in chronic schizophrenia, nine male patients participated in a double-blind crossover comparison of a single intravenous 20-mg injection of beta-endorphin and saline. Bolus injection of beta-endorphin from an albumin-coated syringe produced markedly higher plasma concentrations than did slow intravenous infusion from a non-albumin-coated syringe. Beta-endorphin intravenously injected in nine patients produced a statistically significant increase in serum prolactin levels. In one patient, both 10 mg of morphine sulfate and 20 mg of beta-endorphin produced similar increases in the alpha power of the EEG. In eight patients, beta-endorphin administration was associated with a statistically significant but not clinically obvious improvement in schizophrenic symptoms.

publication date

  • August 8, 1980

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7387335

Additional Document Info

start page

  • 635

end page

  • 40

volume

  • 37

number

  • 6