Zinc-induced activation of human B lymphocytes Academic Article Article uri icon


MeSH Major

  • Asthma


  • The in vitro effect of zinc chloride on human peripheral blood lymphocytes (PBL) was studied in a plaque-forming cell assay. Following in vitro culture in the presence of zinc for 6 days, PBL from normal donors were found to contain activated lymphocytes capable of inducing lysis of sheep red blood cells. Microscopic enumeration of these plaque-forming cells indicated that zinc is as strongly stimulating to human B cells as pokeweed mitogen, purified protein derivative, or diphtheria toxoid. Splenic B cells and lymph node B cells were also activated by zinc as indicated by a positive plaque-forming cell response. In contrast, PBL from patients with hypogammaglobulinemia and spleen cells from one of these patients cultured with zinc failed to produce plaque-forming cells. Study of zinc activation of plaque-forming cells in experiments with PBL from healthy donors in which the effect of zinc and purified protein derivative were analyzed separately and together provided evidence that zinc exerts a synergistic effect on B-cell activation. © 1980.

publication date

  • January 1980



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0090-1229(80)90172-5

PubMed ID

  • 6991178

Additional Document Info

start page

  • 115

end page

  • 22


  • 16


  • 1