Time dependent effects of adriamycin and x‐ray therapy on wound healing in the rat Academic Article Article uri icon


MeSH Major

  • Dependovirus
  • Factor VIII
  • Genetic Therapy
  • Genetic Variation
  • Genetic Vectors
  • Hemophilia A


  • Wound healing as measured by wound breaking strength (WBS) was studied in male Fischer rats. Animals were wounded (day 0) and treated with Adriamycin (ADR), x-ray therapy (XRT), or the combination of ADR + XRT. Treatments were either on day -7,0 or +7. Animals were killed on days +14 and +21, and excised wounds were subjected to uniaxial extension and the recording of WBS (grams), hydroxy-proline assay, and collagen fiber diameter measurements. Day 0 treatment yielded WBS averaging 46% (ADR), 41% (XRT), and 26% (ADR + XRT) of control by 21 days. Newly synthesized hydroxyproline (scar collagen) values of day 0 treated animals were 47% (ADR), 66% (XRT), and 39% (ADR + XRT) of control at 21 days. Day -7 treatment yielded similar WBS values. Withholding single agent or combined treatment until day +7 yielded WBS values comparable to control at 14 or 21 days. In this model, day 0 treatment with ADR, XRT, or ADR + XRT impaired WBS most significantly. This was supported by a diminution in newly synthesized hydroxyproline and load extension curve analysis.

publication date

  • January 1980



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19800601)45:11<2805::AID-CNCR2820451115>3.0.CO;2-#

PubMed ID

  • 7379011

Additional Document Info

start page

  • 2805

end page

  • 10


  • 45


  • 11