In vitro mitogenic effect of Zn2+ on peripheral blood lymphocytes in patients with cancer Academic Article uri icon


MeSH Major

  • Asthma


  • The methodology for evaluating the mitogenic effect of Zn2+ on human PBL was standardized in a microtiter system. In normal subjects the maximal PBL transformation response occurred in 6-7 day cultures at a Zn2+ concentration of 0.1-0.5 mM. Utilizing PHA as a reference cell activator, the in vitro PBL response to Zn2+ was evaluated in a heterogeneous population of patients with adenocarcinoma of the breast, epidermoid carcinoma of the head and neck, and lymphoma. In all cases the PBL responses to Zn2+ were depressed in a fashion similar to PHA. Zn2+ appears to be a sensitive activator of PBL and may prove of value in the in vitro immunologic evaluation of patients with cancer. © 1980.

publication date

  • January 1980



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0192-0561(80)90007-7

Additional Document Info

start page

  • 37

end page

  • 40


  • 2


  • 1