CSF monoamine metabolites in depression and schizophrenia Academic Article uri icon

Overview

MeSH Major

  • Depression
  • Schizophrenia

abstract

  • The authors report cerebrospinal fluid (CSF) concentrations of five monoamine metabolites before and after probenecid administration in normal subjects and patients with depression and schizophrenia. No differences were found in baseline metabolite concentrations among the three groups. CSF metabolite and CSF probenecid concentrations were significantly correlated in depressed patients for all metabolites, and there was decreased postprobenecid accumulation of homovanillic acid in the CSF of depressed patients compared with schizophrenic patients and with normal subjects. The authors propose a method for correcting for probenecid concentrations. Data from normal subjects should be of value for other investigators using the probenecid technique.

publication date

  • June 6, 1980

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 7352572

Additional Document Info

start page

  • 174

end page

  • 80

volume

  • 137

number

  • 2