Maintenance of granuloma formation in pulmonary sarcoidosis by T lymphocytes within the lung. Academic Article uri icon

Overview

MeSH

  • Adult
  • Chemotaxis, Leukocyte
  • Female
  • Humans
  • Male
  • Middle Aged
  • Molecular Weight
  • Monocytes
  • Pulmonary Fibrosis

MeSH Major

  • Chemotactic Factors
  • Granuloma
  • Lung
  • Lung Diseases
  • Sarcoidosis
  • T-Lymphocytes

abstract

  • Pulmonary granulomata of sarcoidosis are composed primarily of mononuclear phagocytic cells that are probably derived from blood monocytes. To evaluate the concept that recruitment of blood monocytes to the sarcoid lung is mediated by chemoattractants produced by immune effector cells within the lung, we obtained mononuclear cells from lung and blood of six patients with active pulmonary sarcoidosis, six normal subjects, and six patients with active idiopathic pulmonary fibrosis and studied their ability to secrete a chemotactic factor for monocytes. Lung T lymphocytes from all sarcoidosis patients, but not from normal subjects or patients with idiopathic pulmonary fibrosis, spontaneously secreted such a mediator. Lung T lymphocytes from patients with sarcoidosis secreted more monocyte chemotactic factor than did blood T lymphocytes from the same patients. The accumulation of monocytes in the lung in patients with pulmonary sarcoidosis may be mediated by local production of monocyte chemotactic factor by lung T lymphocytes.

publication date

  • March 13, 1980

has subject area

  • Adult
  • Chemotactic Factors
  • Chemotaxis, Leukocyte
  • Female
  • Granuloma
  • Humans
  • Lung
  • Lung Diseases
  • Male
  • Middle Aged
  • Molecular Weight
  • Monocytes
  • Pulmonary Fibrosis
  • Sarcoidosis
  • T-Lymphocytes

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJM198003133021102

PubMed ID

  • 6965420

Additional Document Info

start page

  • 594

end page

  • 598

volume

  • 302

number

  • 11