Serum enzymes in colorectal cancer Academic Article Article uri icon


MeSH Major

  • Echocardiography
  • Mitral Valve Insufficiency
  • Ultrasonography, Doppler


  • A study of the value of serum enzymes in 184 patients with colorectal cancer has been performed. The enzymes studied were gamma glutamyltransferase (gammaGT), alkaline phosphatase (AP), lactate dehydrogenase (LDH), 5'-nucleotidase (5'-NT), glutathione reductase (GR), alanine and aspartate transaminases. In patients without liver metastases, elevated enzyme levels were found in 11-55% preoperatively. 5'-NT showed the least number of elevated activities, while gammaGT activities were increased in 29% and LDH in 55%. The percentage of elevated enzyme levels rose significantly in the early postoperative period. Patients with liver metastases showed increased enzyme activities in 40-60% preoperatively: gammaGT was the most sensitive indicator. Increased enzyme activity was related to the degree of liver involvement with secondary tumor. With extensive liver metastases, gammaGT levels were increased in 82%. It is concluded that serum enzymes are of limited value in the preoperative detection of liver metastases, and particularly when tumor involvement of the liver is small.

publication date

  • January 1979



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197905)43:5<1772::AID-CNCR2820430529>3.0.CO;2-Y

PubMed ID

  • 36219

Additional Document Info

start page

  • 1772

end page

  • 6


  • 43


  • 5