Amino acid deficiency and the skin rash associated with glucagonoma Academic Article uri icon


MeSH Major

  • Amino Acids
  • Erythema
  • Glucagon
  • Pancreatic Neoplasms


  • A 47-year-old white man had a malignant glucagonoma and severe necrolytic migratory erythema. His plasma glucagon levels were markedly elevated at 50 ng/mL and plasma amino acids diminished to 45% of normal. To test the hypothesis that the skin rash associated with a glucagonoma is secondary to an amino acid deficiency, we obtained 2 d of fasting baseline laboratory data from the patient while he consumed his usual diet. He was then given 3 L/d of supplemental intravenous amino acids for 3 d. His plasma amino acid levels increased slightly, and there was some improvement in his skin rash. Immediately thereafter, total parenteral nutrition was administered for 3 d without added zinc or fatty acids. During total parenteral nutrition, 14 of 17 plasma amino acids became normal, and the patient's skin rash rapidly disappeared. These findings suggest that the skin rash associated with a glucagonoma is most likely due to an amino acid deficiency and can be reversed by parenteral nutrition.

publication date

  • December 1979



  • Academic Article



  • eng

PubMed ID

  • 111595

Additional Document Info

start page

  • 213

end page

  • 5


  • 91


  • 2