Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. Academic Article uri icon

Overview

MeSH

  • Bacterial Infections
  • Cell Count
  • Eosinophils
  • Humans
  • Immunoglobulins
  • Inflammation
  • Lung Neoplasms
  • Lymphocytes
  • Macrophages
  • Neutrophils

MeSH Major

  • Lung
  • Lung Diseases
  • Therapeutic Irrigation

abstract

  • Bronchoalveolar lavage is an invaluable means of accurately evaluating the inflammatory and immune processes of the human lung. Although lavage recovers only those cells and proteins present on the epithelial surface of the lower respiratory tract, comparison with open lung biopsies shows that these constituents are representative of the inflammatory and immune systems of the alveolar structures. With the use of these techniques, sufficient materials are obtained from normal individuals to allow characterization of not only the types of cells and proteins present but their functions as well. Such observations have been useful in defining the inflammatory and immune capabilities of the normal lung and provide a basis for the study of lung disease. Lavage methods have been used to characterize inflammatory and immune processes of the lower respiratory tract in destructive, infectious, neoplastic, and interstitial disorders. From the data already acquired, it is apparent that bronchoalveolar lavage will yield major insights into the pathogenesis, staging, and therapy decisions involved in these disorders. (Am J Pathol 97:149--206, 1979).

publication date

  • October 1979

has subject area

  • Bacterial Infections
  • Cell Count
  • Eosinophils
  • Humans
  • Immunoglobulins
  • Inflammation
  • Lung
  • Lung Diseases
  • Lung Neoplasms
  • Lymphocytes
  • Macrophages
  • Neutrophils
  • Therapeutic Irrigation

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC2042387

PubMed ID

  • 495693

Additional Document Info

start page

  • 149

end page

  • 206

volume

  • 97

number

  • 1