Procollagen α2 mRNA is significantly different from procollagen α1(I) mRNA in size or secondary structure Academic Article Article uri icon


MeSH Major

  • Braces
  • Exercise Therapy
  • Intervertebral Disc
  • Low Back Pain
  • Spinal Diseases


  • The fractionation of fetal calf tendon messenger RNA in 85 percent formamide sucrose gradients shows a separation of the mRNAs coding for pro α1(I) and pro α2 chains of type I collagen. This difference in sedimentation in denaturing gradients suggests that pro α2 mRNA is approxmately 1000 bases shorter than pro α1(I) mRNA. However, such a size difference is significantly greater than would be predicted from consideration of the size of the polypeptide chains coded for by these mRNAs, and thus, residual secondary structure in the mRNAs may contribute to these apparent size differences. © 1979.

publication date

  • April 13, 1979



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/0006-291X(79)92031-X

PubMed ID

  • 454429

Additional Document Info

start page

  • 818

end page

  • 26


  • 87


  • 3