Naloxone blocks amphetamine-induced rearing: Potential interaction between catecholamines and endorphins
1. 1. The effect of 10 mg/kg of naloxone on amphetamine- (1.5 mg/kg) induced behavior was evaluated. 2. 2. Naloxone did not alter amphetamine-induced hyperactivity or stereotypy, but did selectively block rearing behavior. 3. 3. This effect raises two interesting issues: a) It suggests that the first phase of amphetamine-induced behavior in rats (hypermotility) might be considered as having two subcomponents modulated by different mechanisms; b) It adds support to an already growing literature on possible catecholamine-endorphin interactions. © 1978.
Digital Object Identifier (DOI)
Additional Document Info
has global citation frequency