Naloxone blocks amphetamine-induced rearing: Potential interaction between catecholamines and endorphins Academic Article uri icon

Overview

MeSH Major

  • Cryopreservation
  • Kidney Diseases
  • Kidney Transplantation
  • Organ Preservation
  • Perfusion

abstract

  • 1. 1. The effect of 10 mg/kg of naloxone on amphetamine- (1.5 mg/kg) induced behavior was evaluated. 2. 2. Naloxone did not alter amphetamine-induced hyperactivity or stereotypy, but did selectively block rearing behavior. 3. 3. This effect raises two interesting issues: a) It suggests that the first phase of amphetamine-induced behavior in rats (hypermotility) might be considered as having two subcomponents modulated by different mechanisms; b) It adds support to an already growing literature on possible catecholamine-endorphin interactions. © 1978.

publication date

  • January 1978

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/0364-7722(78)90100-5

Additional Document Info

start page

  • 425

end page

  • 430

volume

  • 2

number

  • 4