Regulation of human mixed lymphocyte culture reactions: augmentation of proliferation and generation of cytotoxic cells Academic Article uri icon


MeSH Major

  • Cytotoxicity, Immunologic
  • Lymphocyte Activation


  • The in vitro proliferation and generation of cytotoxic cells in the mixed lymphocyte culture reaction (MLC) are thought to mimic in vivo cellular immune effector mechanisms operative in allograft rejection. Recent studies have clarified the need for disparity at the D-locus-determined antigens between the stimulator and responder cell populations in the allogeneic MLC reactions. However, very little is known about the initial cell surface interactions of transmembrane propagation of stimulatory signals in the MLC. Since alterations in cell shape or surface architecture could conceivably influence these processes and since the microtubular apparatus is the prime candidate for a cell surface modulating structure, we studied the effect of colchicine (Col), a microtubule disrupting alkaloid, on the allogeneic MLC.

publication date

  • December 1978



  • Academic Article



  • eng

PubMed ID

  • 153618

Additional Document Info

start page

  • 923

end page

  • 5


  • 10


  • 4