Adrenocorticotropin in rat brain: Immunocytochemical localization in cells and axons Academic Article uri icon

Overview

MeSH Major

  • Adrenocorticotropic Hormone
  • Brain
  • Pituitary Gland

abstract

  • By means of antiserum (purified by affinity chromatography) directed against adrenocorticotropin (ACTH) 11-24, cell bodies and beaded axons were visualized in rat brain. The ACTH-like immunoreactivity (ACTH-LI) was primarily located in the hypothalamus (cells and axons). Fibers were scattered throughout thalamus, amygdala, periaqueductal gray area, and reticular formation. There was no change in the distribution of ACTH-LI in rats that had been subjected to hypophysectomy. This distribution of ACTH-LI parallels that of beta-lipotropin and is altered by specific lesions in a similar fashion. The presence of ACTH-LI in cells and beaded axons in brain raises the possibility that it is a neuroregulator functioning as a neurotransmitter, neuromodulator, or neurohormone.

publication date

  • December 1978

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 206967

Additional Document Info

start page

  • 1180

end page

  • 2

volume

  • 200

number

  • 4346