Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E Academic Article uri icon

Overview

MeSH Major

  • Colony-Stimulating Factors
  • Glycoproteins
  • Granulocytes
  • Hematopoiesis
  • Leukocytes
  • Macrophages
  • Monocytes
  • Prostaglandins E

abstract

  • The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.

publication date

  • December 1978

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 304600

Additional Document Info

start page

  • 552

end page

  • 5

volume

  • 199

number

  • 4328