Distribution of HLA antigens in idiopathic pulmonary fibrosis. Academic Article uri icon

Overview

MeSH

  • Adult
  • Aged
  • Female
  • Gene Frequency
  • Humans
  • Male
  • Middle Aged
  • Phenotype

MeSH Major

  • HLA Antigens
  • Pulmonary Fibrosis

abstract

  • Divergent observations suggest that genetic factors contribute to the susceptibility to or clinical course of idiopathic pulmonary fibrosis. To determine whether there is an association between the major histocompatibility (HLA) system and idiopathic pulmonary fibrosis, the distribution of 35 antigens of HLA loci A and B was determined among 33 white patients with idiopathic pulmonary fibrosis and 329 healthy white control subjects. Although certain antigens tended to be more prevalent among patients with idiopathic pulmonary fibrosis compared with control subjects, there were no significant differences in the phenotype frequencies of the HLA-A and HLA-B antigens between these 2 groups. Thus, although subtle associations may exist between the HLA loci and idiopathic pulmonary fibrosis, these results indicate that antigens of the HLA-A and HLA-B loci are not linked with major risk factors in this disease.

publication date

  • July 1978

has subject area

  • Adult
  • Aged
  • Female
  • Gene Frequency
  • HLA Antigens
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Pulmonary Fibrosis

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed ID

  • 677553

Additional Document Info

start page

  • 141

end page

  • 147

volume

  • 118

number

  • 1