Iatrogenic lactic acidosis. Association with hypertonic glucose administration in a patient with cancer Academic Article Article uri icon


MeSH Major

  • Dependovirus
  • Factor VIII
  • Genetic Therapy
  • Genetic Variation
  • Genetic Vectors
  • Hemophilia A


  • A case of lactic acidosis associated with the administration of hypertonic glucose to a patient with a bulky undifferentiated carcinoma is presented. Characteristic alterations in amino acid concentrations were observed during the period of lactic acidosis. Resolution of the metabolic abnormalities were seen with discontinuation of glucose infusion. Short-term glucose infusion in a 90 minute iv glucose tolerance test resulted in an increase in serum lactate and appropriate changes in serine, ornithine, taurine, alanine, and arginine despite normal hormonal responsiveness.

publication date

  • January 1978



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197808)42:2<800::AID-CNCR2820420253>3.0.CO;2-O

PubMed ID

  • 679165

Additional Document Info

start page

  • 800

end page

  • 3


  • 42


  • 2